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Axicabtagene ciloleucel 1 × 10⁶ – 2 × 10⁶ CAR T cells/kg to a maximum allowable dose of 2 × 10⁸ CAR T cells per Bag (approximately 68 mL) – Uses, Dosage, and Brands in UAE

Brand Name: YESCARTA
Strength: 2000000 C / 1 Bag | Form: Suspension For Injection
Price in UAE: AED 1788574.50
Available in UAE pharmacies

About Axicabtagene ciloleucel 1 × 10⁶ – 2 × 10⁶ CAR T cells/kg to a maximum allowable dose of 2 × 10⁸ CAR T cells per Bag (approximately 68 mL)

Class: | CAR T-cell therapy Use: | Treatment of adult patients with relapsed or refractory large B-cell lymphoma (LBCL) after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma, and primary mediastinal B-cell lymphoma. Adult dose: | Administer 1 × 10⁶ to 2 × 10⁶ CAR T cells/kg body weight, with a maximum allowable dose of 2 × 10⁸ CAR T cells per bag (approximately 68 mL). Pediatric dose: | Safety and efficacy have not been est

Drug Class

CAR T-cell therapy

Uses & Indications

Treatment of adult patients with relapsed or refractory large B-cell lymphoma (LBCL) after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma, and primary mediastinal B-cell lymphoma.

Storage Requirements

Store at -120°C to -80°C until use. Once thawed, the product should be infused within 30 minutes and should not be refrozen.

Manufacturer & Packaging

Manufacturer: GILEAD SCIENCES IRELAND UC (CARRIGTOHILL-IRELAND), Ireland

Package Size

68ml Infusion Bag (individually packed in a metal cassette)

Price & Supplier

Price in UAE: AED 1788574.50

Dosage Information

Adult Dose

Administer 1 × 10⁶ to 2 × 10⁶ CAR T cells/kg body weight, with a maximum allowable dose of 2 × 10⁸ CAR T cells per bag (approximately 68 mL).

Pediatric Dose

Safety and efficacy have not been established in pediatric patients; not approved for use in individuals under 18 years of age.

Side Effects

Common side effects include cytokine release syndrome (CRS), neurological toxicities (including confusion, seizures, and encephalopathy), fever, fatigue, hypotension, and infections.

Contraindications & Precautions

Hypersensitivity to axicabtagene ciloleucel or any component of the formulation; active uncontrolled infection; and severe or life-threatening hypersensitivity reactions to any component.

Important Warnings

Risk of severe CRS and neurological toxicities; monitor patients closely for signs and symptoms of these conditions. Patients should be treated at facilities experienced in CAR T-cell therapy and have access to supportive care for CRS and neurological events.

Related Medicines in Same Category

See also: Other CAR T-cell therapy medicines available in UAE pharmacies

Brexucabtagene Autoleucel 1 × 10⁶ anti-CD19 CAR-positive viable T cells/kg (Maximum allowable dos Brexucabtagene Autoleucel 2 × 10 ⁶ anti CD19 CAR-positive viable T cells /kg (Maximum allowable dose 2 × 10 ⁶ anti CD19 CAR-positive viable T cells based on patient weight 100 kg)

Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication. The information presented here is specific to medicines available in UAE pharmacies and is regularly updated to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.

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