About Brexucabtagene Autoleucel 1 × 10⁶ anti-CD19 CAR-positive viable T cells/kg (Maximum allowable dos
Class: | CAR T-cell therapy
Use: | Treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL) after at least one prior therapy
Adult dose: | 1 × 10⁶ anti-CD19 CAR-positive viable T cells/kg (maximum dose of 1 × 10⁸ anti-CD19 CAR-positive viable T cells based on patient weight)
Pediatric dose: | Safety and efficacy not established in pediatric patients
Side effects: | Cytokine release syndrome (CRS), neurological toxicities (including encephalopathy), infections, h
Drug Class
CAR T-cell therapy
Uses & Indications
Treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL) after at least one prior therapy
Storage Requirements
Store at -196°C in the vapor phase of liquid nitrogen; do not thaw until ready to use
Manufacturer & Packaging
Manufacturer: GILEAD SCIENCES IRELAND UC (CARRIGTOHILL-IRELAND), Ireland
Package Size
Bag
Price & Supplier
Price in UAE: AED 1924694.00
Dosage Information
Adult Dose
1 × 10⁶ anti-CD19 CAR-positive viable T cells/kg (maximum dose of 1 × 10⁸ anti-CD19 CAR-positive viable T cells based on patient weight)
Pediatric Dose
Safety and efficacy not established in pediatric patients
Side Effects
Cytokine release syndrome (CRS), neurological toxicities (including encephalopathy), infections, hypogammaglobulinemia, and infusion-related reactions
Contraindications & Precautions
Hypersensitivity to any component of the product; active uncontrolled infection; severe pre-existing neurological conditions
Important Warnings
Risk of CRS and neurological toxicities; monitor patients closely for signs of these conditions; ensure availability of supportive care and treatment for CRS (e.g., tocilizumab)
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.