About Cilastatin Sodium 531 mg equivalent to Cilastatin 500 mg,Imipenem Monohydrate 530 mg equivalent to Imipenem 500 mg,Relebactam Monohydrate 263 mg equivalent to Relebactam 250 mg
Class: | Antibacterial combination (Imipenem-cilastatin-relebactam)
Use: | Treatment of complicated urinary tract infections (cUTI), including pyelonephritis, and complicated intra-abdominal infections (cIAI) caused by susceptible bacteria
Adult dose: | 500 mg (Imipenem 500 mg, Cilastatin 500 mg, Relebactam 250 mg) administered intravenously every 6 hours for 4 to 14 days, depending on the severity of the infection
Pediatric dose: | Not established; safety and efficacy in pediatric patient
Drug Class
Antibacterial combination (Imipenem-cilastatin-relebactam)
Uses & Indications
Treatment of complicated urinary tract infections (cUTI), including pyelonephritis, and complicated intra-abdominal infections (cIAI) caused by susceptible bacteria
Storage Requirements
Store at 20°C to 25°C (68°F to 77°F); protect from light; reconstituted solution should be used immediately or stored at 2°C to 8°C (36°F to 46°F) for up to 24 hours
Manufacturer & Packaging
Manufacturer: MERCK SHARP & DOHME B.V. [Haarlem;Netherlands], Netherlands
Package Size
25 Glass Vials
Price & Supplier
Price in UAE: AED 22030.50
Dosage Information
Adult Dose
500 mg (Imipenem 500 mg, Cilastatin 500 mg, Relebactam 250 mg) administered intravenously every 6 hours for 4 to 14 days, depending on the severity of the infection
Pediatric Dose
Not established; safety and efficacy in pediatric patients have not been determined
Side Effects
Nausea, vomiting, diarrhea, headache, rash, and potential for seizures (especially in patients with renal impairment)
Contraindications & Precautions
Known hypersensitivity to imipenem, cilastatin, rebactam, or any component of the formulation; history of severe allergic reactions to beta-lactam antibiotics
Important Warnings
Risk of seizures in patients with CNS disorders or renal impairment; monitor renal function; may cause Clostridium difficile-associated diarrhea; use with caution in patients with a history of seizures or CNS disorders
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.