About Esketamine Hydrochloride
Class: | NMDA receptor antagonist, antidepressant
Use: | Treatment-resistant depression (TRD) in adults, and depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior
Adult dose: | Initial dose of 56 mg administered as a nasal spray, may be increased to 84 mg based on clinical response; typically administered twice a week for the first four weeks, followed by a maintenance phase
Pediatric dose: | Safety and efficacy not established in pedia
Drug Class
NMDA receptor antagonist, antidepressant
Uses & Indications
Treatment-resistant depression (TRD) in adults, and depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior
Storage Requirements
Store in the original carton at 20°C to 25°C (68°F to 77°F); protect from light; do not freeze
Manufacturer & Packaging
Manufacturer: Janssen Cilag International N.V., BELGIUM
Package Size
Device X 1
Price & Supplier
Price in UAE: AED 1238.50
Dosage Information
Adult Dose
Initial dose of 56 mg administered as a nasal spray, may be increased to 84 mg based on clinical response; typically administered twice a week for the first four weeks, followed by a maintenance phase
Pediatric Dose
Safety and efficacy not established in pediatric patients
Side Effects
Dissociation, dizziness, nausea, headache, sedation, increased blood pressure, vomiting
Contraindications & Precautions
Hypersensitivity to esketamine or any component of the formulation; history of aneurysmal vascular disease or arteriovenous malformation; concurrent use of monoamine oxidase inhibitors (MAOIs)
Important Warnings
Risk of sedation and dissociation; potential for abuse and misuse; monitor blood pressure before, during, and after administration; not for use in patients with a history of substance use disorder; may cause suicidal thoughts or behaviors in some patients
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.