About Glucarpidase
Class: | Enzyme (carboxypeptidase G2)
Use: | Treatment of toxic plasma methotrexate concentrations in patients with delayed methotrexate clearance due to impaired renal function
Adult dose: | 1000 U IV over 5-15 minutes; may repeat once after 24 hours if methotrexate levels remain elevated
Pediatric dose: | 1000 U IV over 5-15 minutes; may repeat once after 24 hours if methotrexate levels remain elevated (dosing based on clinical judgment)
Side effects: | Nausea, vomiting, headache, dizz
Drug Class
Enzyme (carboxypeptidase G2)
Uses & Indications
Treatment of toxic plasma methotrexate concentrations in patients with delayed methotrexate clearance due to impaired renal function
Storage Requirements
Store at 2°C to 8°C (36°F to 46°F); do not freeze; protect from light
Manufacturer & Packaging
Manufacturer: Serb Laboratories, FRANCE
Package Size
1's
Price & Supplier
Price in UAE: AED 125240.00
Dosage Information
Adult Dose
1000 U IV over 5-15 minutes; may repeat once after 24 hours if methotrexate levels remain elevated
Pediatric Dose
1000 U IV over 5-15 minutes; may repeat once after 24 hours if methotrexate levels remain elevated (dosing based on clinical judgment)
Side Effects
Nausea, vomiting, headache, dizziness, rash, hypersensitivity reactions
Contraindications & Precautions
Hypersensitivity to glucarpidase or any component of the formulation; caution in patients with a history of severe allergic reactions
Important Warnings
Risk of hypersensitivity reactions; monitor for signs of anaphylaxis; may interfere with methotrexate serum concentration assays; ensure appropriate monitoring of methotrexate levels after administration
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.