About Interferon Alpha (Natural Human Leukocytic) (ISMAFRON)
Class: | Antiviral and Antineoplastic Agent
Use: | Interferon Alpha (Natural Human Leukocytic) is used for the treatment of various viral infections such as chronic hepatitis B and C, and certain types of cancer, including hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma.
Adult dose: | The standard adult dosing varies depending on the condition being treated. For chronic hepatitis B, the typical dose is 5 million international units (MIU) daily or 10 MIU three times a
Drug Class
Antiviral and Antineoplastic Agent
Uses & Indications
Interferon Alpha (Natural Human Leukocytic) is used for the treatment of various viral infections such as chronic hepatitis B and C, and certain types of cancer, including hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma.
Storage Requirements
Store the powder for solution for injection in a refrigerator at 2°C to 8°C (36°F to 46°F). Protect from light and do not freeze. Reconstituted solutions should be used immediately or stored according to the manufacturer's instructions.
Manufacturer & Packaging
Manufacturer: Alpha-Chem Advanced Pharmaceutical Industries (ACCAPI), EGYPT
Package Size
1 Vial (Lyophilisate) + 1 Solvent Ampoule (3ml)
Price & Supplier
Price in UAE: AED 1486.00
Dosage Information
Adult Dose
The standard adult dosing varies depending on the condition being treated. For chronic hepatitis B, the typical dose is 5 million international units (MIU) daily or 10 MIU three times a week subcutaneously or intramuscularly. For chronic hepatitis C, the dose is usually 3 MIU three times a week. For cancer treatments, dosing regimens can vary significantly and should be individualized based on the specific condition and patient response.
Pediatric Dose
Pediatric dosing is not well established and should be determined by a healthcare professional based on the specific condition and patient needs.
Side Effects
Common side effects include flu-like symptoms (fever, chills, fatigue, muscle aches), headache, nausea, vomiting, diarrhea, and injection site reactions. More serious side effects can include depression, liver dysfunction, and hematologic abnormalities.
Contraindications & Precautions
Contraindications include hypersensitivity to interferon alpha or any component of the formulation, autoimmune hepatitis, and decompensated liver disease in patients with cirrhosis. Caution is advised in patients with a history of severe psychiatric conditions, cardiac disease, or seizures.
Important Warnings
Important safety warnings include the risk of severe psychiatric adverse effects, including depression and suicidal ideation. Patients should be monitored for signs of depression and other psychiatric symptoms. Use with caution in patients with pre-existing cardiac conditions due to the risk of exacerbation. Regular monitoring of liver function, blood counts, and thyroid function is recommended during treatment.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.