About Lepirudin
Class: | Anticoagulant (direct thrombin inhibitor)
Use: | Lepirudin is used for the treatment of patients with heparin-induced thrombocytopenia (HIT) and for the management of thromboembolic disorders.
Adult dose: | The initial dose is typically 0.4 mg/kg as a bolus, followed by a continuous infusion of 0.15 mg/kg/hour, adjusted based on activated partial thromboplastin time (aPTT) monitoring.
Pediatric dose: | Safety and efficacy in pediatric patients have not been established; therefore,
Drug Class
Anticoagulant (direct thrombin inhibitor)
Uses & Indications
Lepirudin is used for the treatment of patients with heparin-induced thrombocytopenia (HIT) and for the management of thromboembolic disorders.
Storage Requirements
Store at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light.
Manufacturer & Packaging
Manufacturer: Behring GmbH, GERMANY
Package Size
1ml Vial
Price & Supplier
Price in UAE: AED 253.58
Dosage Information
Adult Dose
The initial dose is typically 0.4 mg/kg as a bolus, followed by a continuous infusion of 0.15 mg/kg/hour, adjusted based on activated partial thromboplastin time (aPTT) monitoring.
Pediatric Dose
Safety and efficacy in pediatric patients have not been established; therefore, lepirudin is not recommended for use in this population.
Side Effects
Common side effects include bleeding, injection site reactions, hypotension, and allergic reactions.
Contraindications & Precautions
Contraindicated in patients with active bleeding, severe renal impairment (creatinine clearance <30 mL/min), and known hypersensitivity to lepirudin or any component of the formulation.
Important Warnings
Monitor for signs of bleeding; use with caution in patients with renal impairment. Lepirudin may cause anaphylactic reactions in sensitive individuals. Regular aPTT monitoring is essential to avoid over-anticoagulation.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.