About Ivacaftor,Lumacaftor
Class: | Cystic fibrosis transmembrane conductance regulator (CFTR) modulator
Use: | Treatment of cystic fibrosis in patients aged 2 years and older who have two copies of the F508del mutation in the CFTR gene
Adult dose: | Ivacaftor 150 mg orally every 12 hours with fat-containing food; Lumacaftor 200 mg orally once daily with fat-containing food
Pediatric dose: | For patients aged 2 to 5 years: Ivacaftor 75 mg orally every 12 hours with fat-containing food; Lumacaftor 100 mg orally once
Drug Class
Cystic fibrosis transmembrane conductance regulator (CFTR) modulator
Uses & Indications
Treatment of cystic fibrosis in patients aged 2 years and older who have two copies of the F508del mutation in the CFTR gene
Storage Requirements
Store at room temperature (20°C to 25°C or 68°F to 77°F); protect from moisture
Manufacturer & Packaging
Manufacturer: Vertex Pharmaceuticals Inc, U.S.A
Package Size
112's
Price & Supplier
Price in UAE: AED 84156.80
Dosage Information
Adult Dose
Ivacaftor 150 mg orally every 12 hours with fat-containing food; Lumacaftor 200 mg orally once daily with fat-containing food
Pediatric Dose
For patients aged 2 to 5 years: Ivacaftor 75 mg orally every 12 hours with fat-containing food; Lumacaftor 100 mg orally once daily with fat-containing food
Side Effects
Common side effects include headache, nausea, diarrhea, abdominal pain, and elevated liver enzymes
Contraindications & Precautions
Hypersensitivity to Ivacaftor, Lumacaftor, or any component of the formulation; caution in patients with liver impairment
Important Warnings
Risk of hepatotoxicity; monitor liver function tests before and during treatment; may cause respiratory events; not recommended for use in patients with advanced liver disease
Related Medicines in Same Category
See also: Other Cystic fibrosis transmembrane conductance regulator (CFTR) modulator medicines available in UAE pharmacies
ELEXACAFTOR MORNING,Tezacaftor (Morning),Ivacaftor (Morning),Ivacaftor (Night)
Elexacaftor (morning),Tezacaftor (Morning),Ivacaftor (Morning),Ivacaftor (Night)
Ivacaftor,Tezacaftor
Lumacaftor,Ivacaftor
Lumacaftor,Ivacaftor
Lumacaftor,Ivacaftor
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.