About Sapropterin Hydrochloride (Dihydrochloride)
Class: | Amino Acid Metabolite, Phenylalanine Hydroxylase Activator
Use: | Treatment of phenylketonuria (PKU) in patients with tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency
Adult dose: | Initial: 10 mg/kg/day; may be increased to a maximum of 20 mg/kg/day based on response and tolerability
Pediatric dose: | Initial: 10 mg/kg/day for children aged 1 year and older; may be increased to a maximum of 20 mg/kg/day based on response and tolerability
Side effects: | Headac
Drug Class
Amino Acid Metabolite, Phenylalanine Hydroxylase Activator
Uses & Indications
Treatment of phenylketonuria (PKU) in patients with tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency
Storage Requirements
Store at 20°C to 25°C (68°F to 77°F); protect from moisture and light; keep out of reach of children
Manufacturer & Packaging
Manufacturer: BioMarin International Limited, IRELAND
Package Size
30's
Price & Supplier
Price in UAE: AED 3933.00
Dosage Information
Adult Dose
Initial: 10 mg/kg/day; may be increased to a maximum of 20 mg/kg/day based on response and tolerability
Pediatric Dose
Initial: 10 mg/kg/day for children aged 1 year and older; may be increased to a maximum of 20 mg/kg/day based on response and tolerability
Side Effects
Headache, nausea, vomiting, abdominal pain, diarrhea, fatigue, and irritability
Contraindications & Precautions
Hypersensitivity to sapropterin or any component of the formulation; severe renal impairment
Important Warnings
Monitor phenylalanine levels regularly; may not be effective in all patients with PKU; use caution in patients with a history of depression or suicidal thoughts; potential for allergic reactions
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.