About Metformin Hydrochloride Ph. Eur.,Sitagliptin Hydrochloride 54.48 mg ( corresponds to Sitagliptin Hydrochloride monohydrate 56.69 mg)corresponds to Sitagliptin 50 mg
Class: | Metformin Hydrochloride: Biguanide; Sitagliptin: Dipeptidyl Peptidase-4 (DPP-4) Inhibitor
Use: | Used for the management of type 2 diabetes mellitus to improve glycemic control in adults when diet and exercise are not sufficient.
Adult dose: | Typically, one tablet containing Metformin Hydrochloride 1000 mg and Sitagliptin 50 mg taken once or twice daily with meals. Dosage may be adjusted based on efficacy and tolerability.
Pediatric dose: | Safety and efficacy in pediatric patients hav
Drug Class
Metformin Hydrochloride: Biguanide; Sitagliptin: Dipeptidyl Peptidase-4 (DPP-4) Inhibitor
Uses & Indications
Used for the management of type 2 diabetes mellitus to improve glycemic control in adults when diet and exercise are not sufficient.
Storage Requirements
Store at room temperature, between 20°C to 25°C (68°F to 77°F), in a tightly closed container, protected from moisture.
Manufacturer & Packaging
Manufacturer: Apotex Inc., CANADA
Package Size
56's (14's Blister X 4 )
Price & Supplier
Price in UAE: AED 80.50
Dosage Information
Adult Dose
Typically, one tablet containing Metformin Hydrochloride 1000 mg and Sitagliptin 50 mg taken once or twice daily with meals. Dosage may be adjusted based on efficacy and tolerability.
Pediatric Dose
Safety and efficacy in pediatric patients have not been established.
Side Effects
Common side effects include gastrointestinal symptoms (e.g., diarrhea, nausea, vomiting), headache, upper respiratory tract infection, and hypoglycemia when used with insulin or insulin secretagogues.
Contraindications & Precautions
Contraindicated in patients with severe renal impairment (eGFR <30 mL/min/1.73 m²), metabolic acidosis, including diabetic ketoacidosis, and hypersensitivity to any of the components.
Important Warnings
Risk of lactic acidosis with metformin use, especially in patients with renal impairment or conditions predisposing to hypoxia. Sitagliptin may cause pancreatitis; discontinue if suspected. Monitor renal function before and during treatment.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.