About Crizanlizumab
Class: | Monoclonal antibody (selective P-selectin inhibitor)
Use: | Treatment of sickle cell disease to reduce the frequency of vaso-occlusive crises
Adult dose: | 5 mg/kg administered as an intravenous infusion every 2 weeks; may be increased to 7.5 mg/kg based on clinical response
Pediatric dose: | 5 mg/kg administered as an intravenous infusion every 2 weeks for patients aged 16 years and older; safety and efficacy in patients under 16 years have not been established
Side effects: |
Drug Class
Monoclonal antibody (selective P-selectin inhibitor)
Uses & Indications
Treatment of sickle cell disease to reduce the frequency of vaso-occlusive crises
Storage Requirements
Store in the refrigerator at 2°C to 8°C (36°F to 46°F); do not freeze; protect from light; may be stored at room temperature (up to 25°C or 77°F) for up to 24 hours before use
Manufacturer & Packaging
Manufacturer: Novartis Pharmaceuticals Corporation, U.S.A
Package Size
1 Glass Vial (10 mg/ml)
Price & Supplier
Price in UAE: AED 7163.50
Dosage Information
Adult Dose
5 mg/kg administered as an intravenous infusion every 2 weeks; may be increased to 7.5 mg/kg based on clinical response
Pediatric Dose
5 mg/kg administered as an intravenous infusion every 2 weeks for patients aged 16 years and older; safety and efficacy in patients under 16 years have not been established
Side Effects
Headache, nausea, fatigue, abdominal pain, infusion-related reactions, and musculoskeletal pain
Contraindications & Precautions
Hypersensitivity to crizanlizumab or any component of the formulation; caution in patients with a history of severe allergic reactions
Important Warnings
Risk of infusion-related reactions; monitor patients during and after infusion; potential for increased risk of infections; not recommended for use in patients with active or serious infections
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.