About PEGylated recombinant human Factor VIII
Class: | Hemostatic agent, Antihemophilic factor (recombinant)
Use: | Treatment and prevention of bleeding episodes in patients with hemophilia A (congenital factor VIII deficiency)
Adult dose: | Individualized based on severity of hemophilia and clinical response; typically, 20 to 40 IU/kg every 2 to 3 days for prophylaxis, or higher doses for on-demand treatment
Pediatric dose: | Individualized based on weight and clinical response; generally similar to adult dosing, with adjustments mad
Drug Class
Hemostatic agent, Antihemophilic factor (recombinant)
Uses & Indications
Treatment and prevention of bleeding episodes in patients with hemophilia A (congenital factor VIII deficiency)
Storage Requirements
Store lyophilized powder at 2°C to 8°C (36°F to 46°F); do not freeze; protect from light; reconstituted solution should be used within 3 hours if stored at room temperature
Manufacturer & Packaging
Manufacturer: BAXALTA US Inc., U.S.A
Package Size
1 Glass Vial (5 ml) lyophilized antihemophilic factor (Recombinant) PEGylated + 1 Glass Vial (5 ml) solvent + 1 BAXJECT II Hi-Flow Needleless Transfer Device
Price & Supplier
Price in UAE: AED 5535.50
Dosage Information
Adult Dose
Individualized based on severity of hemophilia and clinical response; typically, 20 to 40 IU/kg every 2 to 3 days for prophylaxis, or higher doses for on-demand treatment
Pediatric Dose
Individualized based on weight and clinical response; generally similar to adult dosing, with adjustments made for younger patients
Side Effects
Headache, nausea, infusion site reactions, fever, arthralgia, and potential for development of inhibitors to factor VIII
Contraindications & Precautions
Known hypersensitivity to PEGylated recombinant factor VIII or any component of the formulation; history of severe allergic reactions to factor VIII products
Important Warnings
Risk of thromboembolic events; monitor for signs of allergic reactions; patients should be monitored for the development of inhibitors; use caution in patients with a history of cardiovascular disease
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.