About Andexanet Alfa
Class: | Antidote (Factor Xa inhibitor reversal agent)
Use: | Reversal of anticoagulation effects of Factor Xa inhibitors (e.g., rivaroxaban, apixaban) in patients with life-threatening or uncontrolled bleeding
Adult dose: | Initial bolus of 400 mg IV over 30 minutes, followed by a maintenance infusion of 4 mg/min for up to 120 minutes; total dose not to exceed 800 mg
Pediatric dose: | Safety and efficacy not established in pediatric patients
Side effects: | Thromboembolic events, infusi
Drug Class
Antidote (Factor Xa inhibitor reversal agent)
Uses & Indications
Reversal of anticoagulation effects of Factor Xa inhibitors (e.g., rivaroxaban, apixaban) in patients with life-threatening or uncontrolled bleeding
Storage Requirements
Store at 2°C to 8°C (36°F to 46°F); do not freeze; protect from light; reconstituted solution should be used immediately or stored at room temperature for up to 8 hours
Manufacturer & Packaging
Manufacturer: AstraZeneca AB. [Sodertalje;Sweden], Sweden
Package Size
4 Glass Vials (20 mL)
Price & Supplier
Price in UAE: AED 64663.50
Dosage Information
Adult Dose
Initial bolus of 400 mg IV over 30 minutes, followed by a maintenance infusion of 4 mg/min for up to 120 minutes; total dose not to exceed 800 mg
Pediatric Dose
Safety and efficacy not established in pediatric patients
Side Effects
Thromboembolic events, infusion site reactions, headache, nausea, fatigue
Contraindications & Precautions
History of severe allergic reactions to andexanet alfa; known hypersensitivity to any component of the formulation
Important Warnings
Risk of thromboembolic events; monitor for signs and symptoms of thrombosis; not indicated for patients with active bleeding due to other causes or in patients receiving anticoagulants other than Factor Xa inhibitors
Related Medicines in Same Category
See also: Other Antidote (Factor Xa inhibitor reversal agent) medicines available in UAE pharmacies
Andexanet Alpha
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.