About Andexanet Alpha
Class: | Antidote (Factor Xa inhibitor reversal agent)
Use: | Reversal of anticoagulation effects of factor Xa inhibitors (e.g., rivaroxaban, apixaban) in patients with life-threatening or uncontrolled bleeding
Adult dose: | Initial bolus of 400 mg IV over 30 minutes, followed by a maintenance infusion of 4 mg/min for up to 120 minutes (total maximum dose of 800 mg)
Pediatric dose: | Safety and efficacy not established in pediatric patients; not recommended for use in this population
Sid
Drug Class
Antidote (Factor Xa inhibitor reversal agent)
Uses & Indications
Reversal of anticoagulation effects of factor Xa inhibitors (e.g., rivaroxaban, apixaban) in patients with life-threatening or uncontrolled bleeding
Storage Requirements
Store at 2°C to 8°C (36°F to 46°F); do not freeze; protect from light; once reconstituted, use immediately or store at room temperature for up to 8 hours
Manufacturer & Packaging
Manufacturer: Portola Netherlands B.V., Netherlands
Package Size
Pack of 4's
Price & Supplier
Price in UAE: AED 89470.00
Dosage Information
Adult Dose
Initial bolus of 400 mg IV over 30 minutes, followed by a maintenance infusion of 4 mg/min for up to 120 minutes (total maximum dose of 800 mg)
Pediatric Dose
Safety and efficacy not established in pediatric patients; not recommended for use in this population
Side Effects
Thromboembolic events, infusion site reactions, headache, nausea, and fatigue
Contraindications & Precautions
Known hypersensitivity to andexanet alfa or any component of the formulation; not indicated for patients receiving anticoagulants other than factor Xa inhibitors
Important Warnings
Risk of thromboembolic events; monitor for signs and symptoms of thrombosis; not a substitute for anticoagulation; may not reverse the effects of all anticoagulants; use caution in patients with a history of thromboembolic events
Related Medicines in Same Category
See also: Other Antidote (Factor Xa inhibitor reversal agent) medicines available in UAE pharmacies
Andexanet Alfa
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.