About Aandexanet Alfa
Class: | Antidote, specific reversal agent for anticoagulants
Use: | Reversal of anticoagulation effects of factor Xa inhibitors (e.g., rivaroxaban, apixaban) in patients with life-threatening or uncontrolled bleeding
Adult dose: | 200 mg administered as a bolus intravenous injection, followed by a continuous infusion of 400 mg over 2 hours; may repeat bolus if needed based on clinical response
Pediatric dose: | Safety and efficacy not established in pediatric patients; not recommended for
Drug Class
Antidote, specific reversal agent for anticoagulants
Uses & Indications
Reversal of anticoagulation effects of factor Xa inhibitors (e.g., rivaroxaban, apixaban) in patients with life-threatening or uncontrolled bleeding
Storage Requirements
Store lyophilized powder at 2°C to 8°C (36°F to 46°F); do not freeze; protect from light; reconstituted solution should be used immediately or stored at room temperature for up to 8 hours
Manufacturer & Packaging
Manufacturer: Alexion Pharmaceuticals Inc, United States of America
Package Size
Vial x 4's
Price & Supplier
Price in UAE: AED 76612.00
Dosage Information
Adult Dose
200 mg administered as a bolus intravenous injection, followed by a continuous infusion of 400 mg over 2 hours; may repeat bolus if needed based on clinical response
Pediatric Dose
Safety and efficacy not established in pediatric patients; not recommended for use in this population
Side Effects
Thromboembolic events, infusion site reactions, headache, nausea, fatigue, and hypersensitivity reactions
Contraindications & Precautions
History of severe allergic reactions to andexanet alfa; known or suspected thromboembolic disease; patients requiring urgent surgical intervention
Important Warnings
Risk of thromboembolic events; monitor for signs and symptoms of thrombosis; not indicated for patients on other anticoagulants or for patients with active bleeding not related to factor Xa inhibitors
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.