About Leflunomide
Class: | Disease-modifying antirheumatic drug (DMARD)
Use: | Leflunomide is primarily used for the treatment of active rheumatoid arthritis to reduce signs and symptoms, inhibit structural damage, and improve physical function.
Adult dose: | The standard adult dosing begins with a loading dose of 100 mg once daily for 3 days, followed by a maintenance dose of 20 mg once daily. Some patients may tolerate 10 mg once daily better.
Pediatric dose: | Leflunomide is not typically recommended for pedia
Drug Class
Disease-modifying antirheumatic drug (DMARD)
Uses & Indications
Leflunomide is primarily used for the treatment of active rheumatoid arthritis to reduce signs and symptoms, inhibit structural damage, and improve physical function.
Storage Requirements
Store at room temperature, between 20°C to 25°C (68°F to 77°F), in a tightly closed container, away from moisture and light.
Manufacturer & Packaging
Manufacturer: Aventis Pharma Deutschland GmbH, GERMANY
Package Size
3's Blister
Price & Supplier
Price in UAE: AED 211.00
Dosage Information
Adult Dose
The standard adult dosing begins with a loading dose of 100 mg once daily for 3 days, followed by a maintenance dose of 20 mg once daily. Some patients may tolerate 10 mg once daily better.
Pediatric Dose
Leflunomide is not typically recommended for pediatric use as safety and efficacy have not been established in children.
Side Effects
Common side effects include diarrhea, elevated liver enzymes, alopecia (hair loss), rash, nausea, and hypertension.
Contraindications & Precautions
Leflunomide is contraindicated in patients with known hypersensitivity to leflunomide or any of its components, in pregnant women due to teratogenicity, and in patients with severe hepatic impairment.
Important Warnings
Leflunomide carries a boxed warning for hepatotoxicity and risk of severe liver injury, which can be fatal. It is also teratogenic and contraindicated in pregnancy. Women of childbearing potential should use effective contraception during treatment and undergo a drug elimination procedure if pregnancy is planned. Regular monitoring of liver function tests is recommended.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.