About Avapritinib
Class: | Tyrosine kinase inhibitor
Use: | Treatment of adults with unresectable or metastatic gastrointestinal stromal tumors (GISTs) with a mutation in the KIT gene, specifically for those with PDGFRA D842V mutations.
Adult dose: | 100 mg orally once daily, taken with or without food.
Pediatric dose: | Safety and efficacy have not been established in pediatric patients; not recommended for use in this population.
Side effects: | Nausea, fatigue, diarrhea, abdominal pain, vomiting, heada
Drug Class
Tyrosine kinase inhibitor
Uses & Indications
Treatment of adults with unresectable or metastatic gastrointestinal stromal tumors (GISTs) with a mutation in the KIT gene, specifically for those with PDGFRA D842V mutations.
Storage Requirements
Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F). Keep in original container to protect from moisture.
Manufacturer & Packaging
Manufacturer: Blueprint Medicines, Netherlands
Package Size
30's
Price & Supplier
Price in UAE: AED 77265.00
Dosage Information
Adult Dose
100 mg orally once daily, taken with or without food.
Pediatric Dose
Safety and efficacy have not been established in pediatric patients; not recommended for use in this population.
Side Effects
Nausea, fatigue, diarrhea, abdominal pain, vomiting, headache, and peripheral edema.
Contraindications & Precautions
Hypersensitivity to avapritinib or any of its components; severe hepatic impairment (Child-Pugh Class C).
Important Warnings
Risk of serious adverse reactions including intracranial hemorrhage, cardiomyopathy, and embryo-fetal toxicity; monitor for signs of bleeding and cardiac function. Avoid use in pregnancy.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.