About Sacubitril,Valsartan
Class: | Angiotensin receptor neprilysin inhibitor (ARNI)
Use: | Treatment of heart failure with reduced ejection fraction (HFrEF) to reduce the risk of cardiovascular death and hospitalization for heart failure
Adult dose: | Initial dose is 49 mg sacubitril/51 mg valsartan (one tablet) twice daily; may be increased to 97 mg sacubitril/102 mg valsartan (one tablet) twice daily after 2-4 weeks, based on tolerability
Pediatric dose: | Safety and efficacy not established in pediatric patients
Drug Class
Angiotensin receptor neprilysin inhibitor (ARNI)
Uses & Indications
Treatment of heart failure with reduced ejection fraction (HFrEF) to reduce the risk of cardiovascular death and hospitalization for heart failure
Storage Requirements
Store at room temperature (20°C to 25°C or 68°F to 77°F); protect from moisture and light
Manufacturer & Packaging
Manufacturer: Novartis Pharma Schweiz AG, SWITZERLAND
Package Size
56's (14's Blister x 4)
Price & Supplier
Price in UAE: AED 747.00
Dosage Information
Adult Dose
Initial dose is 49 mg sacubitril/51 mg valsartan (one tablet) twice daily; may be increased to 97 mg sacubitril/102 mg valsartan (one tablet) twice daily after 2-4 weeks, based on tolerability
Pediatric Dose
Safety and efficacy not established in pediatric patients; not recommended for use in children
Side Effects
Hypotension, hyperkalemia, cough, dizziness, renal impairment, angioedema
Contraindications & Precautions
History of angioedema related to previous ACE inhibitor or ARNI therapy, concomitant use with ACE inhibitors, pregnancy, severe hepatic impairment
Important Warnings
Risk of hypotension, renal impairment, and hyperkalemia; monitor renal function and electrolytes; not recommended for use during pregnancy due to potential fetal harm; risk of angioedema; should not be used with ACE inhibitors or within 36 hours of last dose of an ACE inhibitor
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.