About Amifostine
Class: | Cytoprotective agent
Use: | Amifostine is used to reduce the risk of xerostomia (dry mouth) in patients undergoing radiation therapy for head and neck cancer and to prevent nephrotoxicity associated with cisplatin chemotherapy.
Adult dose: | The typical adult dose for xerostomia is 200 mg/m² administered subcutaneously 30 minutes prior to radiation therapy. For nephroprotection during cisplatin therapy, the dose is 910 mg/m² administered intravenously over 15 minutes prior to cispla
Drug Class
Cytoprotective agent
Uses & Indications
Amifostine is used to reduce the risk of xerostomia (dry mouth) in patients undergoing radiation therapy for head and neck cancer and to prevent nephrotoxicity associated with cisplatin chemotherapy.
Storage Requirements
Store the reconstituted solution at room temperature and use within 24 hours. Unreconstituted powder should be stored at room temperature, away from moisture and light.
Manufacturer & Packaging
Manufacturer: MedImmune Pharma BV, NETHERLANDS
Package Size
1 Vial (Lyophilisate)
Price & Supplier
Price in UAE: AED 1020.00
Dosage Information
Adult Dose
The typical adult dose for xerostomia is 200 mg/m² administered subcutaneously 30 minutes prior to radiation therapy. For nephroprotection during cisplatin therapy, the dose is 910 mg/m² administered intravenously over 15 minutes prior to cisplatin administration.
Pediatric Dose
Safety and efficacy in pediatric patients have not been established; therefore, specific pediatric dosing is not available.
Side Effects
Common side effects include hypotension, nausea, vomiting, flushing, and dizziness.
Contraindications & Precautions
Contraindicated in patients with a known hypersensitivity to amifostine or any of its components, and in patients with severe renal impairment.
Important Warnings
Use with caution in patients with hypotension, dehydration, or those receiving antihypertensive medications. Monitor blood pressure closely during administration.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.