About Evolocumab
Class: | PCSK9 inhibitor
Use: | Adjunctive therapy to diet and maximally tolerated statin therapy for the treatment of adults with hyperlipidemia, including primary hyperlipidemia (heterozygous familial hypercholesterolemia) and atherosclerotic cardiovascular disease (ASCVD) to reduce LDL-C levels.
Adult dose: | 140 mg subcutaneously every 2 weeks or 420 mg subcutaneously once a month.
Pediatric dose: | Not established; safety and efficacy in pediatric patients have not been determined.
Drug Class
PCSK9 inhibitor
Uses & Indications
Adjunctive therapy to diet and maximally tolerated statin therapy for the treatment of adults with hyperlipidemia, including primary hyperlipidemia (heterozygous familial hypercholesterolemia) and atherosclerotic cardiovascular disease (ASCVD) to reduce LDL-C levels.
Storage Requirements
Store in the refrigerator at 2°C to 8°C (36°F to 46°F). Can be kept at room temperature (up to 25°C or 77°F) for up to 30 days. Do not freeze.
Manufacturer & Packaging
Manufacturer: Amgen Europe B.V., NETHERLANDS
Package Size
2 Pre-filled Pen
Price & Supplier
Price in UAE: AED 2254.50
Dosage Information
Adult Dose
140 mg subcutaneously every 2 weeks or 420 mg subcutaneously once a month.
Pediatric Dose
Not established; safety and efficacy in pediatric patients have not been determined.
Side Effects
Common side effects include injection site reactions, nasopharyngitis, upper respiratory tract infections, and myalgia.
Contraindications & Precautions
Hypersensitivity to evolocumab or any component of the formulation.
Important Warnings
Risk of hypersensitivity reactions; monitor for signs of allergic reactions. Not a substitute for statin therapy; should be used in conjunction with a statin or other lipid-lowering therapies.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.