About Difelikefalin
Class: | Opioid receptor agonist
Use: | Treatment of pruritus associated with chronic kidney disease in adults on dialysis
Adult dose: | 0.5 mcg/kg administered as an intravenous bolus over 30 seconds, up to a maximum of 50 mcg per dose, given once daily
Pediatric dose: | Safety and efficacy not established in pediatric patients
Side effects: | Nausea, dizziness, headache, somnolence, and potential for opioid-related adverse effects
Contraindications: | Hypersensitivity to difelikefali
Drug Class
Opioid receptor agonist
Uses & Indications
Treatment of pruritus associated with chronic kidney disease in adults on dialysis
Storage Requirements
Store at 20°C to 25°C (68°F to 77°F); protect from light and do not freeze
Manufacturer & Packaging
Manufacturer: Vifor France, France
Package Size
1ml Vial x 3
Price & Supplier
Price in UAE: AED 686.00
Dosage Information
Adult Dose
0.5 mcg/kg administered as an intravenous bolus over 30 seconds, up to a maximum of 50 mcg per dose, given once daily
Pediatric Dose
Safety and efficacy not established in pediatric patients
Side Effects
Nausea, dizziness, headache, somnolence, and potential for opioid-related adverse effects
Contraindications & Precautions
Hypersensitivity to difelikefalin or any component of the formulation; caution in patients with a history of substance use disorder
Important Warnings
Risk of serious respiratory depression; monitor for sedation and respiratory depression, especially in opioid-naive patients; potential for abuse and dependence; not for use in patients with severe hepatic impairment
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.