About Lumacaftor,Ivacaftor
Class: | Cystic fibrosis transmembrane conductance regulator (CFTR) modulator
Use: | Treatment of cystic fibrosis in patients aged 2 years and older who have two copies of the F508del mutation in the CFTR gene
Adult dose: | Lumacaftor 400 mg and Ivacaftor 250 mg taken orally every 12 hours
Pediatric dose: | For children aged 2 to 5 years: Lumacaftor 100 mg and Ivacaftor 125 mg taken orally every 12 hours; for children aged 6 to 11 years: Lumacaftor 200 mg and Ivacaftor 125 mg taken orally
Drug Class
Cystic fibrosis transmembrane conductance regulator (CFTR) modulator
Uses & Indications
Treatment of cystic fibrosis in patients aged 2 years and older who have two copies of the F508del mutation in the CFTR gene
Storage Requirements
Store at room temperature (20°C to 25°C or 68°F to 77°F) in a tightly closed container, protected from moisture and light
Manufacturer & Packaging
Manufacturer: Vertex Pharmaceuticals Inc, U.S.A
Package Size
112s
Price & Supplier
Price in UAE: AED 84157.00
Dosage Information
Adult Dose
Lumacaftor 400 mg and Ivacaftor 250 mg taken orally every 12 hours
Pediatric Dose
For children aged 2 to 5 years: Lumacaftor 100 mg and Ivacaftor 125 mg taken orally every 12 hours; for children aged 6 to 11 years: Lumacaftor 200 mg and Ivacaftor 125 mg taken orally every 12 hours
Side Effects
Common side effects include respiratory events (e.g., cough, nasal congestion), gastrointestinal disturbances (e.g., diarrhea, abdominal pain), headache, and elevated liver enzymes
Contraindications & Precautions
Contraindicated in patients with a history of hypersensitivity to lumacaftor, ivacaftor, or any component of the formulation; caution in patients with hepatic impairment
Important Warnings
Important safety warnings include the risk of liver injury; monitor liver function tests prior to and during treatment; may cause cataracts in pediatric patients; use caution in patients with a history of liver disease or those taking medications that affect liver enzymes
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.