About Tacrolimus Monohydrate
Class: | Immunosuppressant, Calcineurin Inhibitor
Use: | Prevention of organ rejection in kidney transplant recipients; treatment of moderate to severe atopic dermatitis in patients who are not adequately controlled with topical therapies.
Adult dose: | Initial dose is typically 0.1 to 0.2 mg/kg/day, administered in two divided doses; maintenance dose may be adjusted based on therapeutic drug monitoring and clinical response.
Pediatric dose: | For kidney transplant: Initial dose is usually
Drug Class
Immunosuppressant, Calcineurin Inhibitor
Uses & Indications
Prevention of organ rejection in kidney transplant recipients; treatment of moderate to severe atopic dermatitis in patients who are not adequately controlled with topical therapies.
Storage Requirements
Store at room temperature (20°C to 25°C or 68°F to 77°F); protect from light and moisture; keep out of reach of children.
Manufacturer & Packaging
Manufacturer: Astellas Pharma Ltd., UNITED KINGDOM
Package Size
50 Sachets
Price & Supplier
Price in UAE: AED 469.28
Dosage Information
Adult Dose
Initial dose is typically 0.1 to 0.2 mg/kg/day, administered in two divided doses; maintenance dose may be adjusted based on therapeutic drug monitoring and clinical response.
Pediatric Dose
For kidney transplant: Initial dose is usually 0.15 to 0.2 mg/kg/day in two divided doses; for atopic dermatitis: Dosing is based on weight and clinical response, typically starting at 0.1 mg/kg/day.
Side Effects
Common side effects include tremors, headache, gastrointestinal disturbances (nausea, diarrhea), hypertension, hyperglycemia, and increased risk of infections.
Contraindications & Precautions
Hypersensitivity to tacrolimus or any component of the formulation; concurrent use with certain drugs that significantly affect tacrolimus metabolism (e.g., strong CYP3A4 inhibitors).
Important Warnings
Increased risk of serious infections and malignancies; monitor renal function and blood pressure; caution in patients with a history of diabetes or hypertension; avoid live vaccines during treatment.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.