About enfortumab vedotin
Class: | Antineoplastic agent, Monoclonal antibody-drug conjugate
Use: | Treatment of locally advanced or metastatic urothelial carcinoma in adults who have previously received a PD-1 or PD-L1 inhibitor and a platinum-containing chemotherapy
Adult dose: | 1.25 mg/kg administered as an intravenous infusion once every week for 3 weeks, followed by a 1-week treatment-free period (28-day cycle)
Pediatric dose: | Safety and effectiveness in pediatric patients have not been established; not reco
Drug Class
Antineoplastic agent, Monoclonal antibody-drug conjugate
Uses & Indications
Treatment of locally advanced or metastatic urothelial carcinoma in adults who have previously received a PD-1 or PD-L1 inhibitor and a platinum-containing chemotherapy
Storage Requirements
Store powder for concentrate at 2°C to 8°C (36°F to 46°F). Do not freeze. Once reconstituted, the solution should be used immediately or stored at 2°C to 8°C for up to 24 hours
Manufacturer & Packaging
Manufacturer: Astellas Pharma Europe B.V., NETHERLANDS
Package Size
VIAL
Price & Supplier
Price in UAE: AED 5123.00
Dosage Information
Adult Dose
1.25 mg/kg administered as an intravenous infusion once every week for 3 weeks, followed by a 1-week treatment-free period (28-day cycle)
Pediatric Dose
Safety and effectiveness in pediatric patients have not been established; not recommended for use in pediatric populations
Side Effects
Fatigue, rash, nausea, diarrhea, peripheral neuropathy, decreased appetite, and increased liver enzymes
Contraindications & Precautions
Hypersensitivity to enfortumab vedotin or any of its components; severe liver impairment (Child-Pugh Class C)
Important Warnings
Risk of severe skin reactions, including rash and pruritus; risk of peripheral neuropathy; monitor for signs of infusion-related reactions; may cause fetal harm; use effective contraception during treatment and for a period after therapy
Related Medicines in Same Category
See also: Other Antineoplastic agent, Monoclonal antibody-drug conjugate medicines available in UAE pharmacies
Polatuzumab vedotin
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.