About Peginterferon alfa-2b (PegiHep)
Class: | Peginterferon alfa-2b is classified as an antiviral and immunomodulatory agent.
Use: | Peginterferon alfa-2b is used for the treatment of chronic hepatitis C in patients with compensated liver disease, often in combination with ribavirin. It may also be used for other viral infections as determined by a healthcare provider.
Adult dose: | The standard adult dosing for Peginterferon alfa-2b is typically 1.5 mcg/kg once weekly as a subcutaneous injection. The duration of treatment can va
Drug Class
Peginterferon alfa-2b is classified as an antiviral and immunomodulatory agent.
Uses & Indications
Peginterferon alfa-2b is used for the treatment of chronic hepatitis C in patients with compensated liver disease, often in combination with ribavirin. It may also be used for other viral infections as determined by a healthcare provider.
Storage Requirements
Store Peginterferon alfa-2b lyophilized powder in a refrigerator at 2°C to 8°C (36°F to 46°F). Protect from light and do not freeze. Reconstituted solution should be used immediately or stored in the refrigerator and used within 24 hours.
Manufacturer & Packaging
Manufacturer: Zydus BioNext, India
Package Size
vial
Price & Supplier
Price in UAE: AED 492.80
Dosage Information
Adult Dose
The standard adult dosing for Peginterferon alfa-2b is typically 1.5 mcg/kg once weekly as a subcutaneous injection. The duration of treatment can vary depending on the genotype of the hepatitis C virus and the patient's response to therapy.
Pediatric Dose
For pediatric patients aged 3 years and older, the dosing is weight-based, typically 60 mcg/m² once weekly as a subcutaneous injection. The specific dose and duration should be determined by a healthcare provider.
Side Effects
Common side effects include flu-like symptoms (fever, fatigue, headache, muscle aches), depression, irritability, insomnia, nausea, and injection site reactions. Some patients may experience more severe side effects such as neutropenia or thrombocytopenia.
Contraindications & Precautions
Peginterferon alfa-2b is contraindicated in patients with hypersensitivity to interferons, autoimmune hepatitis, decompensated liver disease, and in neonates/infants due to benzyl alcohol content. It is also contraindicated in pregnant women when used in combination with ribavirin.
Important Warnings
Important safety warnings include the risk of severe psychiatric effects (e.g., depression, suicidal ideation), autoimmune disorders, ischemic and infectious disorders, and bone marrow suppression. Patients should be monitored closely for these conditions, and therapy should be adjusted or discontinued if necessary. Regular blood tests are recommended to monitor blood cell counts and liver function.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.