About Regorafenib
Class: | Multikinase inhibitor
Use: | Regorafenib is used for the treatment of metastatic colorectal cancer, gastrointestinal stromal tumors (GIST) that cannot be surgically removed and have progressed after treatment with imatinib and sunitinib, and hepatocellular carcinoma (HCC) in patients who have been previously treated with sorafenib.
Adult dose: | The standard adult dose is 160 mg (four 40 mg tablets) taken orally once daily for the first 21 days of each 28-day cycle.
Pediatric dose: | Sa
Drug Class
Multikinase inhibitor
Uses & Indications
Regorafenib is used for the treatment of metastatic colorectal cancer, gastrointestinal stromal tumors (GIST) that cannot be surgically removed and have progressed after treatment with imatinib and sunitinib, and hepatocellular carcinoma (HCC) in patients who have been previously treated with sorafenib.
Storage Requirements
Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Keep the bottle tightly closed to protect from moisture.
Manufacturer & Packaging
Manufacturer: Bayer AG, GERMANY
Package Size
84's (28's Bottle x 3)
Price & Supplier
Price in UAE: AED 18386.50
Dosage Information
Adult Dose
The standard adult dose is 160 mg (four 40 mg tablets) taken orally once daily for the first 21 days of each 28-day cycle.
Pediatric Dose
Safety and efficacy in pediatric patients have not been established.
Side Effects
Common side effects include hand-foot skin reaction, fatigue, diarrhea, decreased appetite, hypertension, and infection.
Contraindications & Precautions
Regorafenib is contraindicated in patients with known severe hypersensitivity to regorafenib or any of its excipients.
Important Warnings
Important safety warnings include hepatotoxicity, hemorrhage, gastrointestinal perforation or fistula, and dermatologic toxicity. Regular monitoring of liver function tests is recommended.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.