About THIOTEPA
Class: | Alkylating agent
Use: | Thiotepa is used primarily in the treatment of various cancers, including breast cancer, ovarian cancer, bladder cancer, and as part of conditioning regimens for bone marrow transplantation.
Adult dose: | The typical adult dose varies depending on the specific treatment protocol and cancer type. For example, in high-dose regimens for bone marrow transplantation, doses can range from 300-900 mg/m². For other cancers, doses may be lower and administered in cycl
Drug Class
Alkylating agent
Uses & Indications
Thiotepa is used primarily in the treatment of various cancers, including breast cancer, ovarian cancer, bladder cancer, and as part of conditioning regimens for bone marrow transplantation.
Storage Requirements
Store at controlled room temperature, typically between 20°C to 25°C (68°F to 77°F). Protect from light and moisture.
Manufacturer & Packaging
Manufacturer: ESTEVE Pharmaceuticals GmbH, Germany
Package Size
1'S
Price & Supplier
Price in UAE: AED 4360.00
Dosage Information
Adult Dose
The typical adult dose varies depending on the specific treatment protocol and cancer type. For example, in high-dose regimens for bone marrow transplantation, doses can range from 300-900 mg/m². For other cancers, doses may be lower and administered in cycles.
Pediatric Dose
Pediatric dosing is highly individualized based on the type of cancer, treatment protocol, and body surface area. Doses can range from 10-15 mg/m² per day for several days, depending on the regimen.
Side Effects
Common side effects include nausea, vomiting, fatigue, myelosuppression (decreased blood cell counts), and increased risk of infection. Other side effects may include mucositis, rash, and alopecia.
Contraindications & Precautions
Thiotepa is contraindicated in patients with hypersensitivity to thiotepa or any component of the formulation. It should not be used in patients with severe bone marrow suppression or severe infections.
Important Warnings
Thiotepa can cause severe myelosuppression, leading to increased risk of infection and bleeding. It is a potent teratogen and should not be used during pregnancy. Patients should be monitored for signs of bone marrow suppression and other toxicities. Use with caution in patients with renal or hepatic impairment.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.