About Ofatumumab
            
            Class: | Monoclonal antibody (CD20 antagonist)  
Use: | Treatment of chronic lymphocytic leukemia (CLL) in combination with chlorambucil in patients who are not candidates for fludarabine-based therapy; also used for the treatment of relapsing forms of multiple sclerosis (RMS)  
Adult dose: | CLL: 300 mg IV on day 1, followed by 200 mg IV weekly for 7 doses, then 200 mg IV every 4 weeks; RMS: 20 mg subcutaneously once a month  
Pediatric dose: | Safety and efficacy not established in pediatric p
         
        
            
                
                
                    
                        Drug Class
                    
                    Monoclonal antibody (CD20 antagonist)
                 
                
                
                    
                        Uses & Indications
                    
                    Treatment of chronic lymphocytic leukemia (CLL) in combination with chlorambucil in patients who are not candidates for fludarabine-based therapy; also used for the treatment of relapsing forms of multiple sclerosis (RMS)
                 
                
                
                    
                        Storage Requirements
                    
                    Store in the refrigerator at 2°C to 8°C (36°F to 46°F); do not freeze; protect from light
                 
                
                
                    
                        Manufacturer & Packaging
                    
                    
                        Manufacturer: Novartis Pharmaceuticals Corporation, U.S.A
                    
                    
                    Package Size
                    50ml Preservative-free Vial
                    
                    
                    Price & Supplier
                    
                        Price in UAE: AED 37352.00
                    
                    
                 
             
            
                
                
                    
                        Dosage Information
                    
                    
                        Adult Dose
                    
                    
                        CLL: 300 mg IV on day 1, followed by 200 mg IV weekly for 7 doses, then 200 mg IV every 4 weeks; RMS: 20 mg subcutaneously once a month
                    
                    
                        Pediatric Dose
                    
                    
                        Safety and efficacy not established in pediatric patients for CLL; not indicated for pediatric use in RMS
                    
                 
                
                
                    
                        Side Effects
                    
                    Infusion-related reactions, infections, headache, fatigue, nausea, diarrhea, rash, and increased liver enzymes
                 
             
         
        
        
            
                Contraindications & Precautions
            
            Active infections, hypersensitivity to ofatumumab or any component of the formulation
         
        
        
            
                Important Warnings
            
            Risk of serious infections, including progressive multifocal leukoencephalopathy (PML); monitor for infusion reactions; premedication may be required to mitigate infusion-related reactions
         
        
        
        
        
        
        
        
        
        
        
            
                Medical Disclaimer
            
            
                This information is for educational purposes only and should not replace professional medical advice. 
                Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication. 
                The information presented here is specific to medicines available in UAE pharmacies and is regularly updated 
                to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.