About Cobimetinib
Class: | MEK inhibitor
Use: | Treatment of unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib
Adult dose: | 60 mg orally once daily for 21 days, followed by 7 days off (28-day cycle)
Pediatric dose: | Safety and efficacy not established in pediatric patients
Side effects: | Diarrhea, rash, nausea, fatigue, elevated liver enzymes, fever
Contraindications: | Hypersensitivity to cobimetinib or any component of the formulation; pregnanc
Uses & Indications
Treatment of unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib
Storage Requirements
Store at 20°C to 25°C (68°F to 77°F); protect from moisture and light
Manufacturer & Packaging
Manufacturer: F. HOFFMANN LA ROCHE LTD, Switzerland
Package Size
63's (21's Blister x 3)
Price & Supplier
Price in UAE: AED 25159.00
Dosage Information
Adult Dose
60 mg orally once daily for 21 days, followed by 7 days off (28-day cycle)
Pediatric Dose
Safety and efficacy not established in pediatric patients
Side Effects
Diarrhea, rash, nausea, fatigue, elevated liver enzymes, fever
Contraindications & Precautions
Hypersensitivity to cobimetinib or any component of the formulation; pregnancy; breastfeeding
Important Warnings
Risk of serious skin reactions, hepatotoxicity, and ocular toxicities; monitor liver function tests and for signs of skin toxicity; not recommended for use in combination with strong CYP3A inhibitors or in patients with severe hepatic impairment.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.