About Selumetinib
Class: | MEK inhibitor
Use: | Treatment of neurofibromatosis type 1 (NF1) in pediatric patients aged 2 years and older with symptomatic, inoperable plexiform neurofibromas
Adult dose: | Not established for adults; primarily studied in pediatric populations
Pediatric dose: | 10 mg/m² orally once daily, with a maximum dose of 50 mg once daily; dosing may be adjusted based on tolerability and response
Side effects: | Common side effects include diarrhea, nausea, vomiting, abdominal pain, fa
Uses & Indications
Treatment of neurofibromatosis type 1 (NF1) in pediatric patients aged 2 years and older with symptomatic, inoperable plexiform neurofibromas
Storage Requirements
Store at room temperature (20°C to 25°C or 68°F to 77°F); protect from moisture and light
Manufacturer & Packaging
Manufacturer: ASTRAZENICA PHARMACEUTICAL LP, United States of America
Package Size
60's HDPE BOTTLE
Price & Supplier
Price in UAE: AED 21611.50
Dosage Information
Adult Dose
Not established for adults; primarily studied in pediatric populations
Pediatric Dose
10 mg/m² orally once daily, with a maximum dose of 50 mg once daily; dosing may be adjusted based on tolerability and response
Side Effects
Common side effects include diarrhea, nausea, vomiting, abdominal pain, fatigue, rash, and elevated liver enzymes
Contraindications & Precautions
Hypersensitivity to selumetinib or any of its components; pregnancy (Category D)
Important Warnings
Risk of serious skin reactions, hepatotoxicity, and cardiomyopathy; monitor liver function tests and cardiac function during treatment; avoid use in pregnant women due to potential fetal harm
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.