About Dabrafenib
Class: | BRAF inhibitor
Use: | Treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations; used in combination with trametinib for BRAF V600E or V600K mutation-positive metastatic melanoma; also indicated for non-small cell lung cancer (NSCLC) with BRAF V600E mutation.
Adult dose: | 150 mg orally twice daily; may be taken with or without food.
Pediatric dose: | Safety and efficacy not established in pediatric patients; use is not recommended in patients under 18 ye
Drug Class
BRAF inhibitor
Uses & Indications
Treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations; used in combination with trametinib for BRAF V600E or V600K mutation-positive metastatic melanoma; also indicated for non-small cell lung cancer (NSCLC) with BRAF V600E mutation.
Storage Requirements
Store at room temperature (20°C to 25°C or 68°F to 77°F); protect from moisture and light; keep out of reach of children.
Manufacturer & Packaging
Manufacturer: Novartis Pharmaceuticals Corporation, U.S.A
Package Size
210's
Price & Supplier
Price in UAE: AED 17751.30
Dosage Information
Adult Dose
150 mg orally twice daily; may be taken with or without food.
Pediatric Dose
Safety and efficacy not established in pediatric patients; use is not recommended in patients under 18 years of age.
Side Effects
Common side effects include fever, fatigue, nausea, vomiting, diarrhea, rash, and joint pain.
Contraindications & Precautions
Hypersensitivity to dabrafenib or any component of the formulation; history of serious hypersensitivity reactions to other BRAF inhibitors.
Important Warnings
Risk of new malignancies (e.g., cutaneous squamous cell carcinoma); serious skin reactions; risk of pyrexia; may cause serious allergic reactions; monitor for signs of hepatotoxicity and other adverse effects.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.