About Glibenclamide,Metformin Hydrochloride
Class: | Antidiabetic combination medication (sulfonylurea and biguanide)
Use: | Management of type 2 diabetes mellitus in adults, particularly in patients who are not adequately controlled on metformin alone.
Adult dose: | Typically, the starting dose is 1 tablet (Glibenclamide 2.5 mg and Metformin 500 mg) taken orally twice daily with meals. Dosing may be adjusted based on blood glucose levels, but the maximum recommended dose is 2 tablets twice daily.
Pediatric dose: | Safety and effica
Drug Class
Antidiabetic combination medication (sulfonylurea and biguanide)
Uses & Indications
Management of type 2 diabetes mellitus in adults, particularly in patients who are not adequately controlled on metformin alone.
Storage Requirements
Store at room temperature (15°C to 30°C or 59°F to 86°F) in a tightly closed container, protected from moisture and light.
Manufacturer & Packaging
Manufacturer: Merck Sante, FRANCE
Package Size
30's (15's Blister x 2)
Price & Supplier
Price in UAE: AED 16.50
Dosage Information
Adult Dose
Typically, the starting dose is 1 tablet (Glibenclamide 2.5 mg and Metformin 500 mg) taken orally twice daily with meals. Dosing may be adjusted based on blood glucose levels, but the maximum recommended dose is 2 tablets twice daily.
Pediatric Dose
Safety and efficacy have not been established in pediatric patients; therefore, use in children is not recommended.
Side Effects
Common side effects include gastrointestinal disturbances (nausea, vomiting, diarrhea), hypoglycemia, headache, dizziness, and abdominal pain.
Contraindications & Precautions
Contraindicated in patients with hypersensitivity to glibenclamide, metformin, or any component of the formulation; severe renal impairment; acute or chronic metabolic acidosis; diabetic ketoacidosis; and in patients with a history of lactic acidosis.
Important Warnings
Risk of lactic acidosis, especially in patients with renal impairment, liver disease, or conditions that may lead to hypoxia. Monitor renal function regularly. Caution in patients with a history of heart failure or those undergoing procedures requiring contrast media. Hypoglycemia may occur; patients should be educated on recognizing symptoms.
Related Medicines in Same Category
See also: Other Antidiabetic combination medication (sulfonylurea and biguanide) medicines available in UAE pharmacies
Glimepiride,Metformin Hydrochloride
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.