About Trametinib Dimethyl Sulfoxide
Class: | Antineoplastic agent, MEK inhibitor
Use: | Treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, in combination with dabrafenib; also used for the treatment of non-small cell lung cancer (NSCLC) with BRAF V600E mutations.
Adult dose: | 2 mg orally once daily, taken continuously until disease progression or unacceptable toxicity; may be adjusted based on tolerability.
Pediatric dose: | Safety and efficacy not established in pediatric patients; use is
Drug Class
Antineoplastic agent, MEK inhibitor
Uses & Indications
Treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, in combination with dabrafenib; also used for the treatment of non-small cell lung cancer (NSCLC) with BRAF V600E mutations.
Storage Requirements
Store at 20°C to 25°C (68°F to 77°F); protect from moisture and light.
Manufacturer & Packaging
Manufacturer: NOVARTIS EUROPHARM LIMITED, IRELAND
Package Size
30's
Price & Supplier
Price in UAE: AED 5521.20
Dosage Information
Adult Dose
2 mg orally once daily, taken continuously until disease progression or unacceptable toxicity; may be adjusted based on tolerability.
Pediatric Dose
Safety and efficacy not established in pediatric patients; use is not recommended.
Side Effects
Common side effects include rash, diarrhea, edema, fatigue, nausea, and elevated liver enzymes.
Contraindications & Precautions
Hypersensitivity to trametinib or any component of the formulation; pregnancy (Category D).
Important Warnings
Risk of serious skin reactions, including rash and dermatitis; risk of cardiomyopathy; monitor for signs of bleeding; may cause fetal harm; avoid use during pregnancy and breastfeeding.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.