About Mercaptopurine
Class: | Antimetabolite, Purine analog
Use: | Treatment of acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML); also used in the treatment of inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis.
Adult dose: | Initial dose is typically 1.5 to 2.5 mg/kg/day, adjusted based on clinical response and tolerance; maximum dose generally does not exceed 150 mg/day.
Pediatric dose: | Initial dose is usually 1.5 to 2.5 mg/kg/day, with careful monitoring a
Drug Class
Antimetabolite, Purine analog
Uses & Indications
Treatment of acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML); also used in the treatment of inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis.
Storage Requirements
Store at room temperature (20-25°C or 68-77°F) in a tightly closed container, protected from moisture and light.
Manufacturer & Packaging
Manufacturer: Roxane Laboratories, U.S.A
Package Size
250's Bottle
Price & Supplier
Price in UAE: AED 991.88
Dosage Information
Adult Dose
Initial dose is typically 1.5 to 2.5 mg/kg/day, adjusted based on clinical response and tolerance; maximum dose generally does not exceed 150 mg/day.
Pediatric Dose
Initial dose is usually 1.5 to 2.5 mg/kg/day, with careful monitoring and adjustments based on tolerance and response; maximum dose should not exceed adult dosing limits.
Side Effects
Common side effects include nausea, vomiting, diarrhea, liver toxicity, bone marrow suppression (leading to increased risk of infection and bleeding), and rash.
Contraindications & Precautions
Known hypersensitivity to mercaptopurine; severe liver dysfunction; concurrent use with allopurinol (requires dose adjustment); pregnancy and breastfeeding (unless benefits outweigh risks).
Important Warnings
Risk of severe myelosuppression; monitor blood counts regularly; potential for hepatotoxicity; increased risk of infections; avoid live vaccines during treatment; caution in patients with a history of liver disease.
Related Medicines in Same Category
See also: Other Antimetabolite, Purine analog medicines available in UAE pharmacies
Thioguanine
Thioguanine
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.