About Neratinib Maleate 48.31 mg equivalent to Neratinib free base 40 mg
Class: | Tyrosine kinase inhibitor
Use: | Treatment of adult patients with early-stage HER2-positive breast cancer, following adjuvant trastuzumab-based therapy
Adult dose: | 240 mg (equivalent to 48.31 mg of Neratinib Maleate) taken orally once daily, starting 1 month after the completion of trastuzumab therapy
Pediatric dose: | Safety and efficacy have not been established in pediatric patients; not recommended for use in this population
Side effects: | Diarrhea, nausea, vomiting, fati
Drug Class
Tyrosine kinase inhibitor
Uses & Indications
Treatment of adult patients with early-stage HER2-positive breast cancer, following adjuvant trastuzumab-based therapy
Storage Requirements
Store at 20°C to 25°C (68°F to 77°F); protect from moisture and light; keep out of reach of children
Manufacturer & Packaging
Manufacturer: Pierre Fabre Medicament [81500 Lavaur;France], France
Package Size
180's HDPE Bottle
Price & Supplier
Price in UAE: AED 26258.50
Dosage Information
Adult Dose
240 mg (equivalent to 48.31 mg of Neratinib Maleate) taken orally once daily, starting 1 month after the completion of trastuzumab therapy
Pediatric Dose
Safety and efficacy have not been established in pediatric patients; not recommended for use in this population
Side Effects
Diarrhea, nausea, vomiting, fatigue, abdominal pain, decreased appetite, rash, and liver enzyme elevations
Contraindications & Precautions
Known hypersensitivity to Neratinib or any of its components; severe hepatic impairment (Child-Pugh Class C)
Important Warnings
Risk of severe diarrhea; monitor for diarrhea and initiate loperamide prophylaxis; hepatotoxicity; caution in patients with a history of liver disease; potential for drug interactions with strong CYP3A4 inhibitors or inducers
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.