About Bosentan
Class: | Endothelin receptor antagonist
Use: | Treatment of pulmonary arterial hypertension (PAH) to improve exercise ability and delay clinical worsening
Adult dose: | Initial dose of 62.5 mg orally twice daily for 4 weeks, then may increase to 125 mg twice daily based on tolerance and response
Pediatric dose: | Not established; safety and efficacy in pediatric patients have not been determined
Side effects: | Headache, flushing, hypotension, liver enzyme elevations, peripheral edema, n
Drug Class
Endothelin receptor antagonist
Uses & Indications
Treatment of pulmonary arterial hypertension (PAH) to improve exercise ability and delay clinical worsening
Storage Requirements
Store at room temperature (20-25°C or 68-77°F); protect from moisture and light
Manufacturer & Packaging
Manufacturer: Pharmascience Inc., CANADA
Package Size
60s
Price & Supplier
Price in UAE: AED 8620.50
Dosage Information
Adult Dose
Initial dose of 62.5 mg orally twice daily for 4 weeks, then may increase to 125 mg twice daily based on tolerance and response
Pediatric Dose
Not established; safety and efficacy in pediatric patients have not been determined
Side Effects
Headache, flushing, hypotension, liver enzyme elevations, peripheral edema, nasal congestion
Contraindications & Precautions
Hypersensitivity to bosentan or any component of the formulation; concurrent use with cyclosporine A or glyburide; pregnancy (category X)
Important Warnings
Risk of hepatotoxicity; monitor liver function tests before and during treatment; may cause fetal harm; not recommended for use in pregnancy; potential for drug interactions with other medications affecting liver enzymes
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.