About Bosentan
Class: | Endothelin receptor antagonist
Use: | Treatment of pulmonary arterial hypertension (PAH) to improve exercise ability and decrease clinical worsening
Adult dose: | Initial dose of 62.5 mg twice daily for 4 weeks, then increase to 125 mg twice daily based on tolerance
Pediatric dose: | Not established; safety and efficacy in pediatric patients have not been fully evaluated
Side effects: | Headache, flushing, hypotension, liver enzyme elevations, peripheral edema
Contraindication
Drug Class
Endothelin receptor antagonist
Uses & Indications
Treatment of pulmonary arterial hypertension (PAH) to improve exercise ability and decrease clinical worsening
Storage Requirements
Store at room temperature (15°C to 30°C or 59°F to 86°F) in a tightly closed container, protected from moisture and light
Manufacturer & Packaging
Manufacturer: Mylan Pharmaceuticals, CANADA
Package Size
56's
Price & Supplier
Price in UAE: AED 6440.00
Dosage Information
Adult Dose
Initial dose of 62.5 mg twice daily for 4 weeks, then increase to 125 mg twice daily based on tolerance
Pediatric Dose
Not established; safety and efficacy in pediatric patients have not been fully evaluated
Side Effects
Headache, flushing, hypotension, liver enzyme elevations, peripheral edema
Contraindications & Precautions
Hypersensitivity to bosentan or any component of the formulation; pregnancy (category X); concurrent use with cyclosporine A or glyburide
Important Warnings
Risk of hepatotoxicity; monitor liver function tests before and during treatment; may cause fetal harm; requires pregnancy testing and effective contraception in females of reproductive potential
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.