Colistimethate Sodium (COLISTIMETHATE SODIUM) – Uses, Dosage & Brands in UAE

About Colistimethate Sodium

Class: | Polymyxin antibiotic Use: | Colistimethate Sodium is used for the treatment of certain infections caused by multi-drug resistant Gram-negative bacteria, including Pseudomonas aeruginosa and Acinetobacter baumannii. It is often reserved for severe infections where other antibiotics are ineffective. Adult dose: | The typical adult dose is 2.5 to 5 mg/kg/day of colistin base activity, divided into 2 to 4 doses. The exact dose may vary based on the severity of the infection and renal func

Drug Class

Polymyxin antibiotic

Uses & Indications

Colistimethate Sodium is used for the treatment of certain infections caused by multi-drug resistant Gram-negative bacteria, including Pseudomonas aeruginosa and Acinetobacter baumannii. It is often reserved for severe infections where other antibiotics are ineffective.

Storage Requirements

Store the powder at room temperature, away from moisture and heat. Once reconstituted, the solution should be used immediately or stored in the refrigerator and used within 24 hours.

Manufacturer & Packaging

Manufacturer: XELLIA PHARMACEUTICALS APS, Denmark

Package Size

10ml Glass Vial x 10

Price & Supplier

Price in UAE: AED 280.50

Dosage Information

Adult Dose

The typical adult dose is 2.5 to 5 mg/kg/day of colistin base activity, divided into 2 to 4 doses. The exact dose may vary based on the severity of the infection and renal function.

Pediatric Dose

For children, the dose is generally 2.5 to 5 mg/kg/day of colistin base activity, divided into 2 to 4 doses. Dosing adjustments may be necessary based on the child's weight and renal function.

Side Effects

Common side effects include nephrotoxicity (kidney damage), neurotoxicity (such as dizziness, tingling, or numbness), and hypersensitivity reactions. Less common side effects can include respiratory issues and gastrointestinal disturbances.

Contraindications & Precautions

Contraindicated in patients with a known hypersensitivity to colistimethate sodium or polymyxins. Caution is advised in patients with renal impairment, neuromuscular disorders, or those concurrently receiving other nephrotoxic or neurotoxic drugs.

Important Warnings

Use with caution in patients with renal impairment due to the risk of nephrotoxicity. Monitor renal function regularly. Neurotoxic effects can occur, especially at higher doses or in patients with impaired renal function. Avoid concurrent use with other neurotoxic or nephrotoxic medications. Use during pregnancy only if clearly needed, as safety in pregnant women has not been established.

Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication. The information presented here is specific to medicines available in UAE pharmacies and is regularly updated to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.

Colistimethate Sodium – Uses, Dosage, and Brands in UAE