About Actinomycin D (Dactinomycin)
Class: | Antineoplastic agent, Antibiotic
Use: | Treatment of various cancers including Wilms' tumor, rhabdomyosarcoma, and testicular cancer; also used in certain cases of gestational trophoblastic neoplasia.
Adult dose: | 12 to 15 mcg/kg IV once every 1 to 2 weeks, depending on the specific cancer being treated and the patient's response.
Pediatric dose: | 15 mcg/kg IV once every 1 to 2 weeks for Wilms' tumor; dosing may vary based on specific indications and protocols.
Side effects: |
Drug Class
Antineoplastic agent, Antibiotic
Uses & Indications
Treatment of various cancers including Wilms' tumor, rhabdomyosarcoma, and testicular cancer; also used in certain cases of gestational trophoblastic neoplasia.
Storage Requirements
Store at room temperature (20-25°C or 68-77°F); protect from light; do not freeze.
Manufacturer & Packaging
Manufacturer: Lundbeck, GERMANY
Package Size
1 Vial
Price & Supplier
Price in UAE: AED 191.30
Dosage Information
Adult Dose
12 to 15 mcg/kg IV once every 1 to 2 weeks, depending on the specific cancer being treated and the patient's response.
Pediatric Dose
15 mcg/kg IV once every 1 to 2 weeks for Wilms' tumor; dosing may vary based on specific indications and protocols.
Side Effects
Nausea, vomiting, myelosuppression (bone marrow suppression), mucositis, alopecia, and potential for secondary malignancies.
Contraindications & Precautions
Hypersensitivity to actinomycin D or any component of the formulation; pregnancy (due to potential teratogenic effects); severe bone marrow suppression.
Important Warnings
Use with caution in patients with liver or kidney impairment; monitor for signs of infection and bleeding due to myelosuppression; potential for severe allergic reactions; avoid use in pregnancy and breastfeeding.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.