About Ezetimibe,Simvastatin
Class: | Antihyperlipidemic combination (Ezetimibe: cholesterol absorption inhibitor; Simvastatin: HMG-CoA reductase inhibitor)
Use: | Used to lower cholesterol levels in patients with primary hyperlipidemia and mixed dyslipidemia, as an adjunct to diet.
Adult dose: | 10 mg/20 mg once daily in the evening; may be adjusted based on lipid levels and patient response.
Pediatric dose: | Not established for children under 10 years; for children 10-17 years, 10 mg/20 mg once daily may be conside
Drug Class
Antihyperlipidemic combination (Ezetimibe: cholesterol absorption inhibitor; Simvastatin: HMG-CoA reductase inhibitor)
Uses & Indications
Used to lower cholesterol levels in patients with primary hyperlipidemia and mixed dyslipidemia, as an adjunct to diet.
Storage Requirements
Store at room temperature (20-25°C or 68-77°F) in a tightly closed container, protected from moisture and light.
Manufacturer & Packaging
Manufacturer: Merck Sharp & Dohme Limited, UNITED KINGDOM
Package Size
28's (7's Blister x 4)
Price & Supplier
Price in UAE: AED 249.00
Dosage Information
Adult Dose
10 mg/20 mg once daily in the evening; may be adjusted based on lipid levels and patient response.
Pediatric Dose
Not established for children under 10 years; for children 10-17 years, 10 mg/20 mg once daily may be considered based on clinical judgment.
Side Effects
Common side effects include headache, abdominal pain, diarrhea, muscle pain, and elevated liver enzymes.
Contraindications & Precautions
Contraindicated in patients with active liver disease, unexplained persistent elevations of hepatic transaminases, hypersensitivity to any component of the formulation, and during pregnancy and lactation.
Important Warnings
Risk of myopathy and rhabdomyolysis, particularly in patients with renal impairment, elderly patients, and those on higher doses of simvastatin or interacting medications. Regular monitoring of liver function tests and lipid levels is recommended.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.