About Protamine Sulfate
Class: | Antidote, Heparin antagonist
Use: | Reversal of heparin anticoagulation, management of heparin overdose
Adult dose: | Initial dose of 1 to 1.5 mg of protamine sulfate per 100 units of heparin administered; may be given as a slow intravenous injection over 10 minutes; maximum dose should not exceed 50 mg.
Pediatric dose: | 0.5 to 1 mg of protamine sulfate per 100 units of heparin administered; dosing should be adjusted based on the specific clinical scenario and patient response.
Drug Class
Antidote, Heparin antagonist
Uses & Indications
Reversal of heparin anticoagulation, management of heparin overdose
Storage Requirements
Store at room temperature (20-25°C or 68-77°F); protect from light; do not freeze.
Manufacturer & Packaging
Manufacturer: KOCSEL ILAC SANAYI VE TICARET A.S , Turkey
Package Size
5ml Glass Vial
Price & Supplier
Price in UAE: AED 102.50
Dosage Information
Adult Dose
Initial dose of 1 to 1.5 mg of protamine sulfate per 100 units of heparin administered; may be given as a slow intravenous injection over 10 minutes; maximum dose should not exceed 50 mg.
Pediatric Dose
0.5 to 1 mg of protamine sulfate per 100 units of heparin administered; dosing should be adjusted based on the specific clinical scenario and patient response.
Side Effects
Hypotension, bradycardia, allergic reactions (including anaphylaxis), flushing, nausea, vomiting, dyspnea.
Contraindications & Precautions
Known hypersensitivity to protamine sulfate, history of fish allergy (due to its source), caution in patients with a history of heparin-induced thrombocytopenia (HIT).
Important Warnings
Monitor for signs of hypersensitivity reactions; administer slowly to avoid rapid changes in blood pressure; use with caution in patients with diabetes (may cause insulin release).
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.