About Protamine Sulfate
Class: | Antidote, Heparin antagonist
Use: | Reversal of heparin anticoagulation, management of heparin overdose
Adult dose: | 1 to 1.5 mg of protamine sulfate for every 100 units of heparin administered, given intravenously; may be adjusted based on activated partial thromboplastin time (aPTT)
Pediatric dose: | 0.5 to 1 mg of protamine sulfate for every 100 units of heparin administered, given intravenously; dosing may vary based on clinical situation and should be guided by aPTT
Side e
Drug Class
Antidote, Heparin antagonist
Uses & Indications
Reversal of heparin anticoagulation, management of heparin overdose
Storage Requirements
Store at room temperature (20-25°C or 68-77°F); protect from light; do not freeze
Manufacturer & Packaging
Manufacturer: Wockhardt Pharmaceuticals (CP Pharma), UNITED KINGDOM
Package Size
Pack of 10 Ampoules x 5ml
Price & Supplier
Price in UAE: AED 454.25
Dosage Information
Adult Dose
1 to 1.5 mg of protamine sulfate for every 100 units of heparin administered, given intravenously; may be adjusted based on activated partial thromboplastin time (aPTT)
Pediatric Dose
0.5 to 1 mg of protamine sulfate for every 100 units of heparin administered, given intravenously; dosing may vary based on clinical situation and should be guided by aPTT
Side Effects
Hypotension, bradycardia, allergic reactions (including anaphylaxis), flushing, nausea, vomiting
Contraindications & Precautions
Known hypersensitivity to protamine sulfate, history of fish allergy (due to fish-derived protamine), caution in patients with a history of heparin-induced thrombocytopenia (HIT)
Important Warnings
Rapid administration can lead to severe hypotension; monitor blood pressure and heart rate during infusion; use cautiously in patients with allergies to fish or those with a history of adverse reactions to protamine sulfate
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.