About Protamine Sulfate
Class: | Antidote, Heparin antagonist
Use: | Protamine sulfate is used to reverse the effects of heparin, particularly in cases of heparin overdose or when rapid anticoagulation reversal is needed, such as before surgical procedures.
Adult dose: | The typical dose is 1 mg of protamine sulfate for every 100 units of heparin administered, with a maximum dose of 50 mg. The dose may be adjusted based on the patient's activated partial thromboplastin time (aPTT) and clinical situation.
Pediatri
Drug Class
Antidote, Heparin antagonist
Uses & Indications
Protamine sulfate is used to reverse the effects of heparin, particularly in cases of heparin overdose or when rapid anticoagulation reversal is needed, such as before surgical procedures.
Storage Requirements
Store at room temperature (20-25°C or 68-77°F) and protect from light. Do not freeze.
Manufacturer & Packaging
Manufacturer: Leo Pharmaceutical Co., DENMARK
Package Size
5ml Ampoule x 5's
Price & Supplier
Price in UAE: AED 150.65
Dosage Information
Adult Dose
The typical dose is 1 mg of protamine sulfate for every 100 units of heparin administered, with a maximum dose of 50 mg. The dose may be adjusted based on the patient's activated partial thromboplastin time (aPTT) and clinical situation.
Pediatric Dose
The recommended dose is 0.5 to 1 mg of protamine sulfate per 100 units of heparin, with careful monitoring of aPTT and clinical response.
Side Effects
Common side effects include hypotension, bradycardia, flushing, and allergic reactions. Rarely, anaphylaxis may occur.
Contraindications & Precautions
Contraindicated in patients with a known hypersensitivity to protamine sulfate or those with a history of fish allergy, as protamine is derived from fish sperm.
Important Warnings
Use with caution in patients with a history of allergies, particularly to fish. Rapid administration may lead to severe hypotension; therefore, it should be administered slowly. Monitor vital signs closely during and after administration.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.