About ENTRECTINIB
Class: | Tyrosine kinase inhibitor
Use: | Treatment of adult and pediatric patients with solid tumors that are positive for NTRK gene fusions, ROS1-positive non-small cell lung cancer (NSCLC), and other tumors with specific genetic alterations
Adult dose: | 600 mg orally once daily; may be taken with or without food
Pediatric dose: | For patients aged 12 years and older, the dose is based on body weight: 600 mg orally once daily for those weighing 45 kg or more; for those weighing less tha
Drug Class
Tyrosine kinase inhibitor
Uses & Indications
Treatment of adult and pediatric patients with solid tumors that are positive for NTRK gene fusions, ROS1-positive non-small cell lung cancer (NSCLC), and other tumors with specific genetic alterations
Storage Requirements
Store at room temperature (20°C to 25°C or 68°F to 77°F); protect from moisture and light
Manufacturer & Packaging
Manufacturer: Genentech, CANADA
Package Size
90'S
Price & Supplier
Price in UAE: AED 50782.50
Dosage Information
Adult Dose
600 mg orally once daily; may be taken with or without food
Pediatric Dose
For patients aged 12 years and older, the dose is based on body weight: 600 mg orally once daily for those weighing 45 kg or more; for those weighing less than 45 kg, the dose is 400 mg orally once daily
Side Effects
Fatigue, dizziness, nausea, diarrhea, constipation, vomiting, edema, and altered taste
Contraindications & Precautions
Hypersensitivity to entrectinib or any component of the formulation; caution in patients with a history of cardiac arrhythmias
Important Warnings
Risk of severe adverse reactions including central nervous system effects, hepatotoxicity, and cardiac toxicity; monitor liver function tests and cardiac function during treatment; may cause embryo-fetal toxicity; advise patients to use effective contraception during treatment and for a period after discontinuation
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.