About Casimersen
Class: | Antisense oligonucleotide
Use: | Casimersen (AMONDYS 45) is used for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 45 skipping.
Adult dose: | Not typically used in adults as it is specifically indicated for pediatric patients with DMD.
Pediatric dose: | The recommended dose is 30 mg/kg administered once weekly as an intravenous infusion over 35 to 60 minutes.
Side effects: | Common side effects inclu
Drug Class
Antisense oligonucleotide
Uses & Indications
Casimersen (AMONDYS 45) is used for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 45 skipping.
Storage Requirements
Store at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. If necessary, the diluted solution can be stored at room temperature for up to 24 hours.
Manufacturer & Packaging
Manufacturer: Sarepta Therapeutics Inc., United States of America
Package Size
2ml Vial
Price & Supplier
Price in UAE: AED 7158.03
Dosage Information
Adult Dose
Not typically used in adults as it is specifically indicated for pediatric patients with DMD.
Pediatric Dose
The recommended dose is 30 mg/kg administered once weekly as an intravenous infusion over 35 to 60 minutes.
Side Effects
Common side effects include upper respiratory tract infections, cough, fever, headache, joint pain, and throat pain.
Contraindications & Precautions
There are no known contraindications. However, hypersensitivity to the active substance or any of the excipients should be considered.
Important Warnings
Monitor renal function as kidney toxicity has been observed with some antisense oligonucleotides. Regular urine tests are recommended to check for proteinuria.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.