About Cilastatin Sodium,Imipenem Monohydrate
Class: | Carbapenem antibiotic (Imipenem) combined with a renal dehydropeptidase inhibitor (Cilastatin)
Use: | Treatment of serious infections caused by susceptible bacteria, including intra-abdominal infections, urinary tract infections, skin and soft tissue infections, and pneumonia.
Adult dose: | 500 mg of Imipenem and 500 mg of Cilastatin administered intravenously every 6 to 8 hours, depending on the severity of the infection.
Pediatric dose: | 15-25 mg/kg of Imipenem and 15-25 mg/kg
Drug Class
Carbapenem antibiotic (Imipenem) combined with a renal dehydropeptidase inhibitor (Cilastatin)
Uses & Indications
Treatment of serious infections caused by susceptible bacteria, including intra-abdominal infections, urinary tract infections, skin and soft tissue infections, and pneumonia.
Storage Requirements
Store at room temperature (20-25°C or 68-77°F) in a dry place; protect from light. Reconstituted solutions should be used immediately or stored at 2-8°C for no more than 24 hours.
Manufacturer & Packaging
Manufacturer: Ranbaxy Laboratories Limited, INDIA
Package Size
1 Glass Vial (Powder)
Price & Supplier
Price in UAE: AED 41.50
Dosage Information
Adult Dose
500 mg of Imipenem and 500 mg of Cilastatin administered intravenously every 6 to 8 hours, depending on the severity of the infection.
Pediatric Dose
15-25 mg/kg of Imipenem and 15-25 mg/kg of Cilastatin administered intravenously every 6 to 8 hours, not to exceed 2 g of Imipenem per day.
Side Effects
Common side effects include nausea, vomiting, diarrhea, rash, and headache. Serious side effects may include seizures, allergic reactions, and Clostridium difficile-associated diarrhea.
Contraindications & Precautions
Known hypersensitivity to Imipenem, Cilastatin, or other beta-lactam antibiotics; history of seizures; and severe renal impairment without appropriate dosage adjustment.
Important Warnings
Use with caution in patients with a history of seizures or CNS disorders; monitor renal function; may cause superinfection with prolonged use; and potential for cross-reactivity in patients allergic to penicillins.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.