About Methotrexate
Class: | Antimetabolite, Antifolate
Use: | Methotrexate is used to treat certain types of cancer (such as breast, skin, head and neck, or lung cancer), severe psoriasis, and rheumatoid arthritis. It works by slowing or stopping the growth of cancer cells and suppressing the immune system.
Adult dose: | For rheumatoid arthritis: 7.5 mg orally once weekly or 2.5 mg every 12 hours for 3 doses per week. For psoriasis: 10-25 mg orally once weekly. For cancer: dosing varies widely based on the type an
Drug Class
Antimetabolite, Antifolate
Uses & Indications
Methotrexate is used to treat certain types of cancer (such as breast, skin, head and neck, or lung cancer), severe psoriasis, and rheumatoid arthritis. It works by slowing or stopping the growth of cancer cells and suppressing the immune system.
Storage Requirements
Store at room temperature, between 20°C to 25°C (68°F to 77°F), away from light and moisture. Keep out of reach of children.
Manufacturer & Packaging
Manufacturer: Orion Pharmaceutical Co., UNITED KINGDOM
Package Size
100s
Price & Supplier
Price in UAE: AED 143.00
Dosage Information
Adult Dose
For rheumatoid arthritis: 7.5 mg orally once weekly or 2.5 mg every 12 hours for 3 doses per week. For psoriasis: 10-25 mg orally once weekly. For cancer: dosing varies widely based on the type and severity of cancer, often ranging from 10-30 mg/m² per week.
Pediatric Dose
For acute lymphoblastic leukemia: 20 mg/m² orally once weekly. Dosing for other conditions is highly variable and should be determined by a pediatric oncologist or specialist.
Side Effects
Common side effects include nausea, vomiting, stomach pain, dizziness, and fatigue. Serious side effects can include liver damage, kidney damage, lung problems, and severe skin reactions.
Contraindications & Precautions
Contraindicated in patients with severe liver or kidney impairment, bone marrow suppression, alcoholism, or chronic liver disease. It is also contraindicated during pregnancy and breastfeeding due to potential harm to the fetus or infant.
Important Warnings
Methotrexate can cause serious or life-threatening side effects. It should only be used under the supervision of a healthcare provider experienced in the use of antimetabolite therapy. Regular monitoring of blood counts, liver and kidney function is necessary. Avoid alcohol and non-prescription NSAIDs due to increased risk of liver damage. Use effective contraception to prevent pregnancy during treatment.
Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.