Arsenic Trioxide (TRISENOX) – Uses, Dosage & Brands in UAE

About Arsenic Trioxide

Class: | Antineoplastic agent, specifically a differentiating agent Use: | Treatment of acute promyelocytic leukemia (APL) in patients who are refractory to or have relapsed after retinoid and anthracycline therapy Adult dose: | Initial dose of 0.15 mg/kg IV daily for 5 days, followed by 0.1 mg/kg IV daily for 5 days in subsequent cycles; may be adjusted based on clinical response and tolerability Pediatric dose: | Safety and efficacy not established; use in pediatric patients should be ba

Drug Class

Antineoplastic agent, specifically a differentiating agent

Uses & Indications

Treatment of acute promyelocytic leukemia (APL) in patients who are refractory to or have relapsed after retinoid and anthracycline therapy

Storage Requirements

Store at 20°C to 25°C (68°F to 77°F); protect from light; do not freeze; discard any unused portion after 24 hours if not refrigerated

Manufacturer & Packaging

Manufacturer: Cephalon, UNITED KINGDOM

Package Size

10ml Ampoule x 10's

Price & Supplier

Price in UAE: AED 28474.00

Dosage Information

Adult Dose

Initial dose of 0.15 mg/kg IV daily for 5 days, followed by 0.1 mg/kg IV daily for 5 days in subsequent cycles; may be adjusted based on clinical response and tolerability

Pediatric Dose

Safety and efficacy not established; use in pediatric patients should be based on clinical judgment and careful monitoring

Side Effects

Common side effects include fatigue, nausea, vomiting, diarrhea, headache, fever, and peripheral neuropathy; serious side effects may include QT prolongation, differentiation syndrome, and liver enzyme elevations

Important Warnings

Monitor for signs of differentiation syndrome, which can be life-threatening; regular monitoring of cardiac function is recommended due to the risk of QT prolongation; avoid use in patients with severe renal impairment without careful consideration of risks and benefits

Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication. The information presented here is specific to medicines available in UAE pharmacies and is regularly updated to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.

Arsenic Trioxide – Uses, Dosage, and Brands in UAE