About Calcium Folinate (Leucovorin Calcium)
Class: | Antidote, Chemoprotective agent
Use: | Used to reduce the toxicity of methotrexate, to treat folate deficiency, and as an adjunct in certain cancer therapies (e.g., in combination with fluorouracil).
Adult dose: | 10 mg to 15 mg administered intravenously or intramuscularly, typically given 24 hours after high-dose methotrexate therapy; dosing may vary based on specific treatment protocols.
Pediatric dose: | 0.5 mg to 1 mg/kg administered intravenously or intramuscularly, typicall
Drug Class
Antidote, Chemoprotective agent
Uses & Indications
Used to reduce the toxicity of methotrexate, to treat folate deficiency, and as an adjunct in certain cancer therapies (e.g., in combination with fluorouracil).
Storage Requirements
Store at room temperature (20-25°C or 68-77°F); protect from light and moisture; do not freeze.
Manufacturer & Packaging
Manufacturer: Bendalis GmbH, GERMANY
Package Size
100ml Vial
Price & Supplier
Price in UAE: AED 267.50
Dosage Information
Adult Dose
10 mg to 15 mg administered intravenously or intramuscularly, typically given 24 hours after high-dose methotrexate therapy; dosing may vary based on specific treatment protocols.
Pediatric Dose
0.5 mg to 1 mg/kg administered intravenously or intramuscularly, typically given 24 hours after high-dose methotrexate therapy; maximum dose should not exceed adult dosing.
Side Effects
Common side effects include nausea, vomiting, diarrhea, abdominal pain, and allergic reactions (e.g., rash, itching).
Contraindications & Precautions
Hypersensitivity to leucovorin or any component of the formulation; should not be used in patients with pernicious anemia or other megaloblastic anemias due to vitamin B12 deficiency.
Important Warnings
Monitor for signs of hypersensitivity; use caution in patients with renal impairment; leucovorin should not be used as a substitute for folic acid in patients with folate deficiency due to vitamin B12 deficiency.
Related Medicines in Same Category
See also: Other Antidote, Chemoprotective agent medicines available in UAE pharmacies
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.