About Calcium Folinate (Leucovorin Calcium)
Class: | Antidote, Chemoprotective Agent
Use: | Used primarily to reduce the toxicity of methotrexate, to treat folate deficiency, and as an adjunct in certain cancer therapies (e.g., in combination with fluorouracil for colorectal cancer).
Adult dose: | 15 mg to 30 mg administered intravenously or intramuscularly, typically given every 6 hours for 4 doses following high-dose methotrexate therapy; for other indications, dosing may vary.
Pediatric dose: | 10 mg/m² to 20 mg/m² administered i
Drug Class
Antidote, Chemoprotective Agent
Uses & Indications
Used primarily to reduce the toxicity of methotrexate, to treat folate deficiency, and as an adjunct in certain cancer therapies (e.g., in combination with fluorouracil for colorectal cancer).
Storage Requirements
Store at room temperature (20°C to 25°C or 68°F to 77°F); protect from light and moisture; do not freeze.
Manufacturer & Packaging
Manufacturer: Hospira Limited, UNITED KINGDOM
Package Size
10's
Price & Supplier
Price in UAE: AED 53.00
Dosage Information
Adult Dose
15 mg to 30 mg administered intravenously or intramuscularly, typically given every 6 hours for 4 doses following high-dose methotrexate therapy; for other indications, dosing may vary.
Pediatric Dose
10 mg/m² to 20 mg/m² administered intravenously or intramuscularly, with dosing frequency depending on the indication and clinical scenario.
Side Effects
Common side effects include nausea, vomiting, diarrhea, abdominal pain, and allergic reactions (e.g., rash, itching).
Contraindications & Precautions
Hypersensitivity to calcium folinate or any component of the formulation; use with caution in patients with a history of allergic reactions to folate or its derivatives.
Important Warnings
Monitor for signs of allergic reactions; use cautiously in patients with renal impairment; not a substitute for folic acid in patients with folate deficiency; overdose can lead to toxicity.
Related Medicines in Same Category
See also: Other Antidote, Chemoprotective Agent medicines available in UAE pharmacies
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.